Research Article | J Oral Health Dent. 2018;1(1):003 | Open Access

Twelve Hour Longevity of the Oral Malodor-Neutralizing Capacity of an Oral Rinse Product Containing the Chlorine Dioxide Precursor Sodium Chlorite

Kerry Grootveld, Edward Lynch and Martin Grootveld

  PDF 

Abstract

Objectives: The objectives of this investigation were to investigate the effectiveness and longevity of an oral rinse product containing 0.10% (w/v) of the chlorine dioxide precursor sodium chlorite (1) on oral malodor in participants throughout a 12 h daylight diurnal cycle.
Materials and methods: Thirty healthy participants (17 male, 13 female) were recruited to the study. Volatile sulfur compound levels (VSCs: H2S, CH3SH and (CH3)2S) were simultaneously monitored in their oral cavity air samples both before (0 h) and at 0.33, 4, 8 and 12 h after using the above oral rinse, or water as a negative control (participants refrained from oral hygiene measures during this 12 h period). The experimental design for this cross-over investigation was a mixed model ANOVA-based system incorporating treatments, sampling time-points and participants, together with their first-order interactions, as components of variance.
Results: Results acquired demonstrated that the oral rinse formulation effectively suppressed VSC production in the oral environment for 12 h periods (p<0.0001, 0.0001 and 0.002 for H2S, CH3SH and (CH3)2S respectively). Mean 0 vs. 12 h reductions in oral cavity H2S and CH3SH concentrations were much greater than those observed for the H2O negative control (p<10-8), but not so for (CH3)2S. Principal component analysis (PCA) a H2S/CH3SH linear combination and (CH3)2S alone significantly loaded on the first and second separate orthogonal components respectively, an observation confirming differing sources for these variable sets.
Conclusions: The oral rinse explored effectively blocked VSC production in the oral cavity for a period of 12 h. This extended efficacy duration is likely to be ascribable to the ability of its active ClO2- ingredient to exert a combination of biochemical (direct VSC- and amino acid VSC precursor-consuming) and microbicidal actions in vivo.
Clinical relevance: The 12 h longevity of product’s# oral malodor-neutralizing actions is of much clinical significance in view of the involvements of VSCs, particularly CH3SH, in the pathogenesis of gingivitis and periodontitis.
#Ultradex™ oral rinse, Venture Life Group plc, UK

Keywords: Oral malodor; Volatile sulfur compounds; Oral rinse; Sodium chlorite; Longevity of oral rinse action

Citation: Grootveld K, Lynch E, Grootveld M. Twelve Hour Longevity of the Oral Malodor-Neutralizing Capacity of an Oral Rinse Product Containing the Chlorine Dioxide Precursor Sodium Chloritea. J Oral Health Dent. 2018;1(1):003